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KMID : 1040320200270020111
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Pediatric Infection & Vaccine
2020 Volume.27 No. 2 p.111 ~ p.116
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Clinical Characteristics of Human Parvovirus B19 Infection in Children
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Jo Kyo-Jin
Lee Yeoun-Joo
Park Kyung-Mi
Yang Eu-Jeen
Yoo Suk-Dong
Lim Taek-Jin
Park Su-Eun
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Abstract
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Purpose: Human parvovirus B19 infection is widespread and has a heterogeneous clinical spectrum, ranging from asymptomatic infection to potentially life-threatening complications. We investigated the various clinical features of human parvovirus B19 infection during an outbreak of the virus in our community.
Methods: A retrospective chart review study was conducted at the Pusan National University Children's Hospital from December 2017 to April 2019. We investigated the clinical features of children with parvovirus B19 immunoglobulin M or parvovirus B19 DNA detected using polymerase chain reaction.
Results: A total of 24 children were diagnosed with parvovirus B19 infection. Twelve (50%) had lace form rashes, and four (16.7%) had petechial rashes. Two (8.3%) were diagnosed with fever without a focus. Six (25%) developed aplastic crisis as a complication of infection, of whom three were previously diagnosed with hereditary spherocytosis and three with acute lymphoblastic leukemia.
Conclusions: In addition to erythema infectiosum, the parvovirus B19 infection can present clinically with various types of rashes and fever without a focus. Furthermore, hematologic manifestations such as neutropenia and aplastic crisis can occur during infection.
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KEYWORD
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Parvovirus, Child, Rash, Aplastic crisis
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